SDZ 216-525

SDZ 216-525
Clinical data
Other names	SDZ-216525; SDZ216525; SDZ216-525
Drug class	Serotonin 5-HT1A receptor antagonist
ATC code	None;
Identifiers
	IUPAC name methyl 4-[4-[4-(1,1,3-trioxo-1,2-benzothiazol-2-yl)butyl]piperazin-1-yl]-1H-indole-2-carboxylate;
CAS Number	141533-35-9 ;
PubChem CID	3037456;
Chemical and physical data
Formula	C25H28N4O5S
Molar mass	496.58 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC(=O)C1=CC2=C(N1)C=CC=C2N3CCN(CC3)CCCCN4C(=O)C5=CC=CC=C5S4(=O)=O;
	InChI InChI=1S/C25H28N4O5S/c1-34-25(31)21-17-19-20(26-21)8-6-9-22(19)28-15-13-27(14-16-28)11-4-5-12-29-24(30)18-7-2-3-10-23(18)35(29,32)33/h2-3,6-10,17,26H,4-5,11-16H2,1H3; Key:LPPRLWFUMJHAKF-UHFFFAOYSA-N;

SDZ 216-525 is a serotonergic drug derived from the phenylpiperazine family which is used in scientific research. It acts as a potent and selective 5-HT_1A receptor antagonist, and is used for research into the function of the 5-HT_1A receptor.^[1]^[2]^[3]^[4]^[5]^[6]

References

↑ Schoeffter P, Fozard JR, Stoll A, Siegl H, Seiler MP, Hoyer D (February 1993). "SDZ 216-525, a selective and potent 5-HT1A receptor antagonist". European Journal of Pharmacology. 244 (3): 251–257. doi:10.1016/0922-4106(93)90150-8. PMID 8384569.
↑ Millan MJ, Rivet JM, Canton H, Le Marouille-Girardon S, Gobert A (March 1993). "Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists". The Journal of Pharmacology and Experimental Therapeutics. 264 (3): 1364–1376. doi:10.1016/S0022-3565(25)10153-5. PMID 8450471.
↑ Lanfumey L, Haj-Dahmane S, Hamon M (November 1993). "Further assessment of the antagonist properties of the novel and selective 5-HT1A receptor ligands (+)-WAY 100 135 and SDZ 216-525". European Journal of Pharmacology. 249 (1): 25–35. doi:10.1016/0014-2999(93)90658-5. PMID 8282017.
↑ Routledge C, Hartley J, Gurling J, Ashworth-Preece M, Brown G, Dourish CT (1994). "In vivo characterization of the putative 5-HT1A receptor antagonist SDZ 216,525 using two models of somatodendritic 5-HT1A receptor function". Neuropharmacology. 33 (3–4): 359–366. doi:10.1016/0028-3908(94)90066-3. PMID 7984274.
↑ Schreiber R, Brocco M, Lefèbvre de Ladonchamps B, Monneyron S, Millan MJ (November 1995). "A drug discrimination analysis of the actions of novel serotonin1A receptor ligands in the rat using the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin". The Journal of Pharmacology and Experimental Therapeutics. 275 (2): 822–831. doi:10.1016/S0022-3565(25)12134-4. PMID 7473172.
↑ Cao BJ, Rodgers RJ (October 1997). "Influence of 5-HT1A receptor antagonism on plus-maze behaviour in mice. II. WAY 100635, SDZ 216-525 and NAN-190". Pharmacology, Biochemistry, and Behavior. 58 (2): 593–603. doi:10.1016/s0091-3057(97)00279-7. PMID 9300624.

This drug article relating to the nervous system is a stub. You can help Wikipedia by adding missing information.

[1] Schoeffter P, Fozard JR, Stoll A, Siegl H, Seiler MP, Hoyer D (February 1993). "SDZ 216-525, a selective and potent 5-HT1A receptor antagonist". European Journal of Pharmacology. 244 (3): 251–257. doi:10.1016/0922-4106(93)90150-8. PMID 8384569.

[2] Millan MJ, Rivet JM, Canton H, Le Marouille-Girardon S, Gobert A (March 1993). "Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists". The Journal of Pharmacology and Experimental Therapeutics. 264 (3): 1364–1376. doi:10.1016/S0022-3565(25)10153-5. PMID 8450471.

[3] Lanfumey L, Haj-Dahmane S, Hamon M (November 1993). "Further assessment of the antagonist properties of the novel and selective 5-HT1A receptor ligands (+)-WAY 100 135 and SDZ 216-525". European Journal of Pharmacology. 249 (1): 25–35. doi:10.1016/0014-2999(93)90658-5. PMID 8282017.

[4] Routledge C, Hartley J, Gurling J, Ashworth-Preece M, Brown G, Dourish CT (1994). "In vivo characterization of the putative 5-HT1A receptor antagonist SDZ 216,525 using two models of somatodendritic 5-HT1A receptor function". Neuropharmacology. 33 (3–4): 359–366. doi:10.1016/0028-3908(94)90066-3. PMID 7984274.

[5] Schreiber R, Brocco M, Lefèbvre de Ladonchamps B, Monneyron S, Millan MJ (November 1995). "A drug discrimination analysis of the actions of novel serotonin1A receptor ligands in the rat using the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin". The Journal of Pharmacology and Experimental Therapeutics. 275 (2): 822–831. doi:10.1016/S0022-3565(25)12134-4. PMID 7473172.

[6] Cao BJ, Rodgers RJ (October 1997). "Influence of 5-HT1A receptor antagonism on plus-maze behaviour in mice. II. WAY 100635, SDZ 216-525 and NAN-190". Pharmacology, Biochemistry, and Behavior. 58 (2): 593–603. doi:10.1016/s0091-3057(97)00279-7. PMID 9300624.

[1]

[2]

[3]

[4]

[5]

[6]

v t e Arylpiperazines
Phenylpiperazines	1-Phenylpiperazine (1-PP; PP) 3,4-CFP 2C-B-PP Acaprazine Antrafenine Aripiprazole Batoprazine Bifeprunox BRL-15,572 Ciprofloxacin Dapiprazole DCPP DMPP Diphenylpiperazine Dropropizine EGIS-7625 EGIS-12,233 Elopiprazole Eltoprazine Enpiprazole Ensaculin Etoperidone Flesinoxan Fluanisone Flibanserin Fluprazine Itraconazole Ketoconazole Levodropropizine Lorpiprazole mCPP Mefway MeOPP Mepiprazole Naftopidil Naluzotan Nefazodone Niaprazine Oxypertine Pardoprunox pCPP pFPP Posaconazole S-14,506 S-14,671 S-15,535 SB-258,585 SB-271,046 SB-357,134 SB-399,885 Sonepiprazole TFMPP Tolpiprazole Trazodone Urapidil Vesnarinone Vilazodone Vortioxetine WAY-100,135 WAY-100,635
Benzylpiperazines	2C-B-BZP 3-Methylbenzylpiperazine Befuraline Bifeprunox Buclizine BZP Chlorbenzoxamine DBZP EGIS-7625 Fipexide Imatinib MBZP MDBZP Meclozine Methoxypiperamide NSI-189 Piberaline Piribedil RN-1747 Sunifiram Trimetazidine Vesnarinone
Naphthylpiperazines	1-Naphthylpiperazine (1-NP) 2-Naphthylpiperazine (2-NP; 1-deazaquipazine) CSP-2503 F-11,461 S-14,506 S-14671
Quinolinylpiperazines	FPPQ 6-Nitroquipazine Isoquipazine Quipazine VCU-1021 (3-methoxyquipazine)
Diphenylalkylpiperazines	AD-1211 Almitrine Amperozide BRL-15,572 Buclizine BW373U86 Cetirizine Chlorbenzoxamine Chlorcyclizine Cinnarizine Clocinizine Cyclizine DBL-583 Diphenpipenol Diphenylmethylpiperazine Dotarizine DPI-221 DPI-287 DPI-3290 GBR-12,783 GBR-12,935 GBR-13,069 GBR-13,098 GBR-13,119 Hydroxyzine JJC8-088 Lidoflazine Manidipine Meclozine MT-45 Oxatomide SNC-80 Vanoxerine
Pyrimidinylpiperazines	Buspirone Dasatinib Eptapirone Gepirone Ipsapirone Piribedil Pyrimidinylpiperazine Revospirone Tandospirone Tirilazad Trimazosin Umespirone Zalospirone
Pyridinylpiperazines	Atevirdine Azaperone Delavirdine Mirtazapine ORG-12962 Pyridinylpiperazine
Benzo(iso)thiazolyl piperazines	Lurasidone Perospirone Revospirone Tiospirone Ziprasidone
Tricyclic-linked piperazines	Amoxapine Clopenthixol Clorotepine Clozapine Cyanothepin Doclothepin Docloxythepin Flupentixol Fluphenazine Isofloxythepin Loxapine Meperathiepin Metitepine Octomethothepin Olanzapine Opipramol Oxyclothepin Oxyprothepin Peradithiepin Perathiepin Perazine Perphenazine Pirenzepine Prochlorperazine Thiethylperazine Thiothixene Trifluoperazine Trifluthepin Zuclopenthixol
Others/uncategorized	AP-238 Azimilide Bucinnazine Cinepazet Cinepazic acid Cinepazide CPD-1 Cyclohexylpiperazine Hexocyclium Indinavir JNJ-7777120 Lodenafil MK-212 Mirodenafil PB-28 Ranolazine SA-4503 Sildenafil Tadalafil Vardenafil VCU-1012 VUF-6002 WY-46824 Zipeprol ZINC000443438219

See also

References