KLK1

KLK1
Identifiers
Aliases	KLK1, KLKR, Klk6, hK1, kallikrein 1
External IDs	OMIM: 147910; MGI: 102850; HomoloGene: 110727; GeneCards: KLK1; OMA:KLK1 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SPJ
Gene location (Human)
Chr.	Chromosome 19 (human)
End	50,823,787 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	43,879,042 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; mucosa of transverse colon; ; parotid gland; ; rectum; ; skin of abdomen; ; islet of Langerhans; ; skin of leg; ; beta cell; ; skin of arm; ; gonad;
	Top expressed in
	submandibular gland; ; parotid gland; ; right kidney; ; left colon; ; human kidney; ; pyloric antrum; ; lacrimal gland; ; crypt of lieberkuhn of small intestine; ; duodenum; ; islet of Langerhans;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; serine-type endopeptidase activity; hydrolase activity;
Cellular component	extracellular exosome; nucleus; secretory granule;
Biological process	proteolysis; regulation of systemic arterial blood pressure; zymogen activation;
	Sources:Amigo / QuickGO
Orthologs
	3816
	16612
	ENSG00000167748
	ENSMUSG00000063903
	P06870
	P15947
	NM_002257
	NM_010639; NM_001320331; NM_001320332
	NP_002248
	NP_001307260; NP_001307261; NP_034769
	Wikidata
View/Edit Human	View/Edit Mouse

Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene.^[5]^[6]^[7] KLK1 is a member of the peptidase S1 family.

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000167748 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063903 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Richards RI, Holman K, Shen Y, Kozman H, Harley H, Brook D, et al. (September 1991). "Human glandular Kallikrein genes: genetic and physical mapping of the KLK1 locus using a highly polymorphic microsatellite PCR marker". Genomics. 11 (1): 77–82. doi:10.1016/0888-7543(91)90103-L. PMID 1684954.
↑ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, et al. (June 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biological Chemistry. 387 (6): 637–641. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
↑ "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biological Chemistry. 387 (6): 635–824. June 2006. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
↑ "Entrez Gene: KLK1 kallikrein 1".

Clements J, Hooper J, Dong Y, Harvey T (January 2001). "The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions". Biological Chemistry. 382 (1): 5–14. doi:10.1515/BC.2001.002. PMID 11258672. S2CID 5864448.
Lottspeich F, Geiger R, Henschen A, Kutzbach C (December 1979). "N-Terminal amino acid sequence of human urinary kallikrein homology with other serine proteases". Hoppe-Seyler's Zeitschrift für Physiologische Chemie. 360 (12): 1947–1950. PMID 393608.
Riegman PH, Vlietstra RJ, Suurmeijer L, Cleutjens CB, Trapman J (September 1992). "Characterization of the human kallikrein locus". Genomics. 14 (1): 6–11. doi:10.1016/S0888-7543(05)80275-7. PMID 1385301.
Henttu P, Lukkarinen O, Vihko P (April 1990). "Expression of the gene coding for human prostate-specific antigen and related hGK-1 in benign and malignant tumors of the human prostate". International Journal of Cancer. 45 (4): 654–660. doi:10.1002/ijc.2910450414. PMID 1691151. S2CID 33875411.
Qin H, Kemp J, Yip MY, Lam-Po-Tang PR, Morris BJ (1992). "Localization of human glandular kallikrein-1 gene to chromosome 19q13.3-13.4 by in situ hybridization". Human Heredity. 41 (4): 222–226. doi:10.1159/000154005. PMID 1783409.
Lu HS, Lin FK, Chao L, Chao J (April 1989). "Human urinary kallikrein. Complete amino acid sequence and sites of glycosylation". International Journal of Peptide and Protein Research. 33 (4): 237–249. doi:10.1111/j.1399-3011.1989.tb01277.x. PMID 2666327.
Angermann A, Bergmann C, Appelhans H (September 1989). "Cloning and expression of human salivary-gland kallikrein in Escherichia coli". The Biochemical Journal. 262 (3): 787–793. doi:10.1042/bj2620787. PMC 1133342. PMID 2686621.
Evans BA, Yun ZX, Close JA, Tregear GW, Kitamura N, Nakanishi S, et al. (May 1988). "Structure and chromosomal localization of the human renal kallikrein gene". Biochemistry. 27 (9): 3124–3129. doi:10.1021/bi00409a003. PMID 2898948.
Fukushima D, Kitamura N, Nakanishi S (December 1985). "Nucleotide sequence of cloned cDNA for human pancreatic kallikrein". Biochemistry. 24 (27): 8037–8043. doi:10.1021/bi00348a030. PMID 3004571.
Kellermann J, Lottspeich F, Geiger R, Deutzmann R (February 1988). "Human urinary kallikrein--amino acid sequence and carbohydrate attachment sites". Protein Sequences & Data Analysis. 1 (3): 177–182. PMID 3163150.
Takahashi S, Irie A, Katayama Y, Ito K, Miyake Y (March 1986). "N-terminal amino acid sequence of human urinary prokallikrein". Journal of Biochemistry. 99 (3): 989–992. doi:10.1093/oxfordjournals.jbchem.a135563. PMID 3635530.
Baker AR, Shine J (December 1985). "Human kidney kallikrein: cDNA cloning and sequence analysis". DNA. 4 (6): 445–450. doi:10.1089/dna.1985.4.445. PMID 3853975.
Del Nery E, Chagas JR, Juliano MA, Prado ES, Juliano L (November 1995). "Evaluation of the extent of the binding site in human tissue kallikrein by synthetic substrates with sequences of human kininogen fragments". The Biochemical Journal. 312 ( Pt 1) (Pt 1): 233–238. doi:10.1042/bj3120233. PMC 1136249. PMID 7492318.
Chen LM, Richards GP, Chao L, Chao J (April 1995). "Molecular cloning, purification and in situ localization of human colon kallikrein". The Biochemical Journal. 307 ( Pt 2) (Pt 2): 481–486. doi:10.1042/bj3070481. PMC 1136673. PMID 7733886.
Clements J, Mukhtar A, Ehrlich A, Yap B (August 1994). "Glandular kallikrein gene expression in the human uterus". Brazilian Journal of Medical and Biological Research = Revista Brasileira de Pesquisas Medicas e Biologicas. 27 (8): 1855–1863. PMID 7749374.
Lin FK, Lin CH, Chou CC, Chen K, Lu HS, Bacheller W, et al. (June 1993). "Molecular cloning and sequence analysis of the monkey and human tissue kallikrein genes". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1173 (3): 325–328. doi:10.1016/0167-4781(93)90131-v. PMID 7916636.
Gomes RA, Juliano L, Chagas JR, Hial V (June 1997). "Characterization of kininogenase activity of an acidic proteinase isolated from human kidney". Canadian Journal of Physiology and Pharmacology. 75 (6): 757–761. doi:10.1139/cjpp-75-6-757. PMID 9276160.
Bourgeois L, Brillard-Bourdet M, Deperthes D, Juliano MA, Juliano L, Tremblay RR, et al. (November 1997). "Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2". The Journal of Biological Chemistry. 272 (47): 29590–29595. doi:10.1074/jbc.272.47.29590. PMID 9368023.
Chen VC, Chao L, Chao J (June 2000). "Reactive-site specificity of human kallistatin toward tissue kallikrein probed by site-directed mutagenesis". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1479 (1–2): 237–246. doi:10.1016/S0167-4838(00)00044-3. PMID 10862973.

External links

The MEROPS online database for peptidases and their inhibitors: S01.160 Archived 2007-11-03 at the Wayback Machine

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000167748 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063903 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Richards_1991-5] Richards RI, Holman K, Shen Y, Kozman H, Harley H, Brook D, et al. (September 1991). "Human glandular Kallikrein genes: genetic and physical mapping of the KLK1 locus using a highly polymorphic microsatellite PCR marker". Genomics. 11 (1): 77–82. doi:10.1016/0888-7543(91)90103-L. PMID 1684954.

[Lundwall_2006-6] Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, et al. (June 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biological Chemistry. 387 (6): 637–641. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.

[pmid16800723-7] "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biological Chemistry. 387 (6): 635–824. June 2006. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.

[entrez-8] "Entrez Gene: KLK1 kallikrein 1".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

v t e Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)
Digestive enzymes	Enteropeptidase Trypsin Chymotrypsin Elastase Neutrophil Pancreatic
Coagulation	factors: Thrombin Factor VIIa Factor IXa Factor Xa Factor XIa Factor XIIa Kallikrein PSA KLK1 KLK2 KLK3 KLK4 KLK5 KLK6 KLK7 KLK8 KLK9 KLK10 KLK11 KLK12 KLK13 KLK14 KLK15 fibrinolysis: Plasmin Plasminogen activator Tissue-type plasminogen activator Urinary plasminogen activator
Complement system	Factor B Factor D Factor I MASP MASP1 MASP2 C3-convertase
Other immune system	Chymase Granzyme Tryptase Proteinase 3/Myeloblastin
Venombin	Ancrod Batroxobin
Other	Acrosin Prolyl endopeptidase Pronase Proprotein convertases 1 2 Prostasin Reelin Subtilisin/Furin/S1P4 Sedolisin/TPP1 Streptokinase Cathepsin A G

KLK1

See also

References

Further reading

External links