Testicular receptor
| nuclear receptor subfamily 2, group C, member 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | NR2C1 | ||||||
| Alt. symbols | TR2 | ||||||
| NCBI gene | 7181 | ||||||
| HGNC | 7971 | ||||||
| OMIM | 601529 | ||||||
| RefSeq | NM_003297 | ||||||
| UniProt | P13056 | ||||||
| Other data | |||||||
| Locus | Chr. 12 q22 | ||||||
| |||||||
| nuclear receptor subfamily 2, group C, member 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | NR2C2 | ||||||
| Alt. symbols | TR4 | ||||||
| NCBI gene | 7182 | ||||||
| HGNC | 7972 | ||||||
| OMIM | 601426 | ||||||
| RefSeq | NM_003298 | ||||||
| UniProt | P49116 | ||||||
| Other data | |||||||
| Locus | Chr. 3 p25 | ||||||
| |||||||
The testicular receptor proteins are members of the nuclear receptor family of intracellular transcription factors.[1] There are two forms of the receptor, TR2 and TR4, each encode by a separate gene (NR2C1 and NR2C2 respectively).[2][3][4] These two receptors are considered orphan receptors, but have important functions as transcription factors. In their role as transcription factors, TR2 and TR4 frequently bind to each other form a heterodimer. For example, as a heterodimer they have an important role in determining what types of hemoglobin are produced in the body.[5]
Historical Members
[edit]Testicular Receptor 3 previously referred to the orphan receptor NR4A1, but it was determined to be part of a different subfamily of nuclear receptors.[6]
References
[edit]- ↑ Lee YF, Lee HJ, Chang C (2002). "Recent advances in the TR2 and TR4 orphan receptors of the nuclear receptor superfamily". J. Steroid Biochem. Mol. Biol. 81 (4–5): 291–308. doi:10.1016/S0960-0760(02)00118-8. PMID 12361719. S2CID 11638283.
- ↑ Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y (1989). "Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains". Biochem. Biophys. Res. Commun. 165 (2): 735–41. Bibcode:1989BBRC..165..735C. doi:10.1016/S0006-291X(89)80028-2. PMID 2597158.
- ↑ Yoshikawa T, DuPont BR, Leach RJ, Detera-Wadleigh SD (1996). "New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene". Genomics. 35 (2): 361–6. doi:10.1006/geno.1996.0368. PMID 8661150.
- ↑ Chang C, Da Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP (1994). "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily". Proc. Natl. Acad. Sci. U.S.A. 91 (13): 6040–4. Bibcode:1994PNAS...91.6040C. doi:10.1073/pnas.91.13.6040. PMC 44133. PMID 8016112.
- ↑ Liu Y, Yang H, Ren M, Yu Q, Xu Q, Fu X (2025-05-31). "Orphan nuclear receptors TR2 and TR4 in erythropoiesis: From mechanisms to therapies". Biomolecules. 15 (6). doi:10.3390/biom15060798. PMC 12191391.
- ↑ Kiriyama Y, Nakatsuma A, Tokumaru H, Sadamoto H, Nochi H (2025). "Functional Changes Associated With the Subcellular Localization of the Nuclear Receptor NR4A1". Biochemistry Research International. 2025 (1). doi:10.1155/bri/4849733. PMC 12313389.
External links
[edit]- nuclear+receptor+subfamily+2,+group+C,+member+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- NR2C2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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