Halotan
 | |
 | |
| Klinički podaci | |
|---|---|
| Prodajno ime | Anestan, Chalothane, Fluktan, Fluothane |
| Drugs.com | Monografija |
| Način primene | Respiratorno (inhalacija) |
| Identifikatori | |
| CAS broj | 151-67-7  |
| ATC kod | N01AB01 (WHO) |
| PubChem | CID 3562 |
| IUPHAR/BPS | 2401 |
| DrugBank | DB01159 |
| ChemSpider | 3441 |
| KEGG | C07515 |
| ChEBI | CHEBI:5615 |
| ChEMBL | CHEMBL931 |
| Hemijski podaci | |
| Formula | C2HBrClF3 |
| Molarna masa | 197,382 |
| |
| |
| Fizički podaci | |
| Tačka topljenja | −118 °C (−180 °F) |
| Tačka ključanja | 502 °C (936 °F) |
Halotan je organsko jedinjenje, koje sadrži 2 atoma ugljenika i ima molekulsku masu od 197,382 Da.[1][2][3]
Osobine
[уреди | уреди извор]| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 0 |
| Broj donora vodonika | 0 |
| Broj rotacionih veza | 1 |
| Particioni koeficijent[4] (ALogP) | 2,5 |
| Rastvorljivost[5] (logS, log(mol/L)) | -2,9 |
| Polarna površina[6] (PSA, Å2) | 0,0 |
Reference
[уреди | уреди извор]- ^ Bovill, J. G. (2008). . „Inhalation anaesthesia: From diethyl ether to xenon”. Handbook of Experimental Pharmacology. 182 (182): 121—142. ISBN 978-3-540-72813-9. PMID 18175089. doi:10.1007/978-3-540-74806-9_6.
- ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). . „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). . „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
- ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). . „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
- ^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). . „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). . „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
[уреди | уреди извор]- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
[уреди | уреди извор]
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
