Paracetamol: Continuous Ultrasound Crystallization in Microfluidic Conditions

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Ultrasound Nucleation

This is an amazing bridge from the projects that my mentor, Jacob Crislip, has moved between. 

Ultrasound with Zeolites

This research paper allows insight on the multiple theories of nucleation caused by ultrasound cavitations. 

Crystallizing Adipic Acid

This research paper provides additional background knowledge of ultrasound crystallization using lactose.

Crystallizing Lactose

This research paper is headed in the direction that we would like to pursue and saves time from a pre-understanding of the physics behind nucleation backed with results.

Temperature Cycling

Paracetamol Polymorphs

This research paper provides insight and background knowledge to the quirks of paracetamol form II, the desired polymorph of our operation as it proves the precise control we have over our current experimental system. 

Paracetamol Form II

This research paper gives additional insight to the effects of swift cooling which we have implemented through microfluidics and how it effects the formation of certain polymorphs of paracetamol.

Swift Cooling Polymorphs

This research paper provides background information for those interested in the specific conditions necessary for the formation of specific polymorphs of paracetamol. These mentioned methods may be applied to other pharmaceutical compounds.

Elusive Polymorphs

This research paper provides insight on the current possibility of production of paracetamol form II in the pharmaceutical industry. 

Production of Form II

Future Plans

This research paper includes cycling tests that we may pull methodologies from.

Cycling

Raman spectroscopy will allow us to differentiate the formation of unique polymorphs by their characteristic peaks by using diffracted photons.

Raman Spectroscopy

This research paper gives us a foundation in calculating growth kinetics for statistical analysis, a requirement in the pharmaceutical industry. 

Growth Kinetics

This research paper allows us to make connections and find or test alternative solutions to the mentioned problems. 

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Paracetamol: Continuous Ultrasound Crystallization in Microfluidic Conditions

Ultrasound Nucleation

Paracetamol Polymorphs

Future Plans

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