Inflammatory responses and inflammation-associated diseases in organs

Chen, Linlin; Deng, Huidan; Cui, Hengmin; Fang, Jing; Zuo, Zhicai; Deng, Junliang; Li, Yinglun; Wang, Xun; Zhao, Ling

doi:10.18632/oncotarget.23208

Oncotarget

2017

DOI: 10.18632/oncotarget.23208

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Inflammatory responses and inflammation-associated diseases in organs

Linlin Chen

¹

,

Huidan Deng

²

,

Hengmin Cui

³

et al.

Abstract: Inflammation is a biological response of the immune system that can be triggered by a variety of factors, including pathogens, damaged cells and toxic compounds. These factors may induce acute and/or chronic inflammatory responses in the heart, pancreas, liver, kidney, lung, brain, intestinal tract and reproductive system, potentially leading to tissue damage or disease. Both infectious and non-infectious agents and cell damage activate inflammatory cells and trigger inflammatory signaling pathways, most commo… Show more

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Cited by 5,209 publications

(3,428 citation statements)

References 167 publications

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Modulatory Effect of Dietary Pentadiplandra brazzeana Baill Root Supplemented Feed in Oedematous and Polyarthritic Rat

2024

TJNPR

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Antiinflammatory agents elicit down-regulation of COX-2 expression and restoration of tumor suppressor p53 level, by increasing the activation of Nrf2 and upregulation of TGF-β. [57][58][59]5 The findings from this study is in congruent with previous reports, showing decreased COX-2 activity and NFκB concentration in PBRF treated rats compared to untreated rats. Agents rich in polyphenols elicit an inhibitory inflammatory response of NF-κB, and upregulate anti-inflammatory gene transcription factors.…”

Section: Results

supporting

confidence: 92%

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Modulatory Effect of Dietary Pentadiplandra brazzeana Baill Root Supplemented Feed in Oedematous and Polyarthritic Rat

2024

TJNPR

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Antiinflammatory agents elicit down-regulation of COX-2 expression and restoration of tumor suppressor p53 level, by increasing the activation of Nrf2 and upregulation of TGF-β. [57][58][59]5 The findings from this study is in congruent with previous reports, showing decreased COX-2 activity and NFκB concentration in PBRF treated rats compared to untreated rats. Agents rich in polyphenols elicit an inhibitory inflammatory response of NF-κB, and upregulate anti-inflammatory gene transcription factors.…”

Section: Results

supporting

confidence: 92%

Get access via publisher

Mitigative Effects of l-Arginine and N-Acetyl Cysteine against Cisplatin-Induced Testicular Dysfunction and Toxicity through the Regulation of Antioxidant, Anti-inflammatory, and Antiapoptotic Markers: Role of miR-155 and miR-34c Expression

Gad

¹

,

Abdelghaffar Emam

²

,

Eldeeb

³

et al. 2024

ACS Omega

Smart CitationsHow this paper cites the one you are viewing

“…67 Serum levels of IL-1β, TNFα, IL-6, and MCP-1 revealed significant increases along with a decline in IL-10 level in CIStreated rats compared with the control group. The present findings agree with an earlier study 68 that reported that CIS can stimulate inflammatory cells and consequently magnifies the inflammatory response through the control of TNF and IL-6 release, resulting in testicular damage. Also, others 69 found that CIS elevates IL-6 and IL-1β levels, and decreases IL-10 levels.…”

Section: Discussion

supporting

confidence: 93%

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Cytogenetic and Ultrastructural Studies of Effects of Antifungal Drug, Fluconazole on Liver of New-born Mice

Attia

¹

,

Matta

²

,

ElMazoudy

³

et al. 2021

BS

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Jensen et al [39] suggested that such cellular infiltration might be due to the presence of necrotic cells which act as an irritant substance attracting the inflammatory cells. In this context, the current results are consistent with the suggestion of Chen et al [40] who stated that the patches of aggregation of inflammatory cells infiltration could be a defence mechanism of the liver against the toxic effect of the drug.…”

Section: Discussion

supporting

confidence: 93%

Get access via publisher

Modulatory Effect of Dietary Pentadiplandra brazzeana Baill Root Supplemented Feed in Oedematous and Polyarthritic Rat

2024

TJNPR

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Antiinflammatory agents elicit down-regulation of COX-2 expression and restoration of tumor suppressor p53 level, by increasing the activation of Nrf2 and upregulation of TGF-β. [57][58][59]5 The findings from this study is in congruent with previous reports, showing decreased COX-2 activity and NFκB concentration in PBRF treated rats compared to untreated rats. Agents rich in polyphenols elicit an inhibitory inflammatory response of NF-κB, and upregulate anti-inflammatory gene transcription factors.…”

Section: Results

supporting

confidence: 92%

Get access via publisher

Mitigative Effects of l-Arginine and N-Acetyl Cysteine against Cisplatin-Induced Testicular Dysfunction and Toxicity through the Regulation of Antioxidant, Anti-inflammatory, and Antiapoptotic Markers: Role of miR-155 and miR-34c Expression

Gad

¹

,

Abdelghaffar Emam

²

,

Eldeeb

³

et al. 2024

ACS Omega

Smart CitationsHow this paper cites the one you are viewing

“…67 Serum levels of IL-1β, TNFα, IL-6, and MCP-1 revealed significant increases along with a decline in IL-10 level in CIStreated rats compared with the control group. The present findings agree with an earlier study 68 that reported that CIS can stimulate inflammatory cells and consequently magnifies the inflammatory response through the control of TNF and IL-6 release, resulting in testicular damage. Also, others 69 found that CIS elevates IL-6 and IL-1β levels, and decreases IL-10 levels.…”

Section: Discussion

supporting

confidence: 93%

Get access via publisher

Cytogenetic and Ultrastructural Studies of Effects of Antifungal Drug, Fluconazole on Liver of New-born Mice

Attia

¹

,

Matta

²

,

ElMazoudy

³

et al. 2021

BS

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Jensen et al [39] suggested that such cellular infiltration might be due to the presence of necrotic cells which act as an irritant substance attracting the inflammatory cells. In this context, the current results are consistent with the suggestion of Chen et al [40] who stated that the patches of aggregation of inflammatory cells infiltration could be a defence mechanism of the liver against the toxic effect of the drug.…”

Section: Discussion

supporting

confidence: 93%

Get access via publisher

Modulatory Effect of Dietary Pentadiplandra brazzeana Baill Root Supplemented Feed in Oedematous and Polyarthritic Rat

2024

TJNPR

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Antiinflammatory agents elicit down-regulation of COX-2 expression and restoration of tumor suppressor p53 level, by increasing the activation of Nrf2 and upregulation of TGF-β. [57][58][59]5 The findings from this study is in congruent with previous reports, showing decreased COX-2 activity and NFκB concentration in PBRF treated rats compared to untreated rats. Agents rich in polyphenols elicit an inhibitory inflammatory response of NF-κB, and upregulate anti-inflammatory gene transcription factors.…”

Section: Results

supporting

confidence: 92%

Get access via publisher

Mitigative Effects of l-Arginine and N-Acetyl Cysteine against Cisplatin-Induced Testicular Dysfunction and Toxicity through the Regulation of Antioxidant, Anti-inflammatory, and Antiapoptotic Markers: Role of miR-155 and miR-34c Expression

Gad

¹

,

Abdelghaffar Emam

²

,

Eldeeb

³

et al. 2024

ACS Omega

Smart CitationsHow this paper cites the one you are viewing

“…67 Serum levels of IL-1β, TNFα, IL-6, and MCP-1 revealed significant increases along with a decline in IL-10 level in CIStreated rats compared with the control group. The present findings agree with an earlier study 68 that reported that CIS can stimulate inflammatory cells and consequently magnifies the inflammatory response through the control of TNF and IL-6 release, resulting in testicular damage. Also, others 69 found that CIS elevates IL-6 and IL-1β levels, and decreases IL-10 levels.…”

Section: Discussion

supporting

confidence: 93%

Get access via publisher

Cytogenetic and Ultrastructural Studies of Effects of Antifungal Drug, Fluconazole on Liver of New-born Mice

Attia

¹

,

Matta

²

,

ElMazoudy

³

et al. 2021

BS

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Jensen et al [39] suggested that such cellular infiltration might be due to the presence of necrotic cells which act as an irritant substance attracting the inflammatory cells. In this context, the current results are consistent with the suggestion of Chen et al [40] who stated that the patches of aggregation of inflammatory cells infiltration could be a defence mechanism of the liver against the toxic effect of the drug.…”

Section: Discussion

supporting

confidence: 93%

Get access via publisher