The meteorology of cytokine storms, and the clinical usefulness of this knowledge

¹

,

²

,

³

et al. 2021

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…61 Excessive or unregulated chronic activation can induce a "cytokine storm" in the brain and result in neurotoxic levels of cytokines and free radicals (e.g., nitric oxide and superoxide), which can damage neurons and initiate a self-perpetuating cycle of inflammatory neurotoxicity. 21,60,62,71 Consistent with work published by others, our CCI-induced moderate TBI provoked activation of microglia and astrocytes in surrounding ipsilateral brain areas (Figures 7 and 8), with a resulting elevation in microglial TNF-α generation (Figure 9). In line with this, significantly lower levels of ramified (resting/ surveillance) microglia expressing P2RY12 were evident in brain ipsilateral to TBI, as compared to the contralateral side (Figure 10C,D).…”

Section: ■ Discussion

supporting

confidence: 89%

N-Adamantyl Phthalimidine: A New Thalidomide-like Drug That Lacks Cereblon Binding and Mitigates Neuronal and Synaptic Loss, Neuroinflammation, and Behavioral Deficits in Traumatic Brain Injury and LPS Challenge

¹

,

²

,

³

et al. 2021

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…61 Excessive or unregulated chronic activation can induce a "cytokine storm" in the brain and result in neurotoxic levels of cytokines and free radicals (e.g., nitric oxide and superoxide), which can damage neurons and initiate a self-perpetuating cycle of inflammatory neurotoxicity. 21,60,62,71 Consistent with work published by others, our CCI-induced moderate TBI provoked activation of microglia and astrocytes in surrounding ipsilateral brain areas (Figures 7 and 8), with a resulting elevation in microglial TNF-α generation (Figure 9). In line with this, significantly lower levels of ramified (resting/ surveillance) microglia expressing P2RY12 were evident in brain ipsilateral to TBI, as compared to the contralateral side (Figure 10C,D).…”

Section: ■ Discussion

supporting

confidence: 89%

Transcriptomic Analysis of the Spleen of Different Chicken Breeds Revealed the Differential Resistance of Salmonella Typhimurium

Elsharkawy

¹

,

Wang

²

,

Ding

³

et al. 2022

Genes

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…The significantly altered pathways after ST infection included neuroactive ligand-receptor interaction and cytokinecytokine receptor interaction, in line with earlier reports [29][30][31]. High doses of Salmonella can result in the production of excess amounts of proinflammatory cytokines, or a "cytokine storm", leading to endotoxin shock or sepsis-related deaths [32][33][34]. Thus, the potential influence of over-expression of inflammatory cytokines due to hypersensitivity response to SE in susceptible birds was also considered in this study.…”

Section: Discussion

supporting

confidence: 80%

Vaping-associated illness: a reassessment

Schiffman

¹

2024

Preprint

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…This can be seen in cytokine storm which has been associated with non-infectious as well as infectious etiologies such as Covid-19 [23]. Cytokine storm can manifest with low albumin level that would be consistent with capillary leak [23][24][25]. Hypoalbuminemia was seen in 12 of 14 patients in this series.…”

Section: Discussion

mentioning

confidence: 67%

N-Adamantyl Phthalimidine: A New Thalidomide-like Drug That Lacks Cereblon Binding and Mitigates Neuronal and Synaptic Loss, Neuroinflammation, and Behavioral Deficits in Traumatic Brain Injury and LPS Challenge

¹

,

²

,

³

et al. 2021

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…61 Excessive or unregulated chronic activation can induce a "cytokine storm" in the brain and result in neurotoxic levels of cytokines and free radicals (e.g., nitric oxide and superoxide), which can damage neurons and initiate a self-perpetuating cycle of inflammatory neurotoxicity. 21,60,62,71 Consistent with work published by others, our CCI-induced moderate TBI provoked activation of microglia and astrocytes in surrounding ipsilateral brain areas (Figures 7 and 8), with a resulting elevation in microglial TNF-α generation (Figure 9). In line with this, significantly lower levels of ramified (resting/ surveillance) microglia expressing P2RY12 were evident in brain ipsilateral to TBI, as compared to the contralateral side (Figure 10C,D).…”

Section: ■ Discussion

supporting

confidence: 89%

Transcriptomic Analysis of the Spleen of Different Chicken Breeds Revealed the Differential Resistance of Salmonella Typhimurium

Elsharkawy

¹

,

Wang

²

,

Ding

³

et al. 2022

Genes

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…The significantly altered pathways after ST infection included neuroactive ligand-receptor interaction and cytokinecytokine receptor interaction, in line with earlier reports [29][30][31]. High doses of Salmonella can result in the production of excess amounts of proinflammatory cytokines, or a "cytokine storm", leading to endotoxin shock or sepsis-related deaths [32][33][34]. Thus, the potential influence of over-expression of inflammatory cytokines due to hypersensitivity response to SE in susceptible birds was also considered in this study.…”

Section: Discussion

supporting

confidence: 80%

Vaping-associated illness: a reassessment

Schiffman

¹

2024

Preprint

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…This can be seen in cytokine storm which has been associated with non-infectious as well as infectious etiologies such as Covid-19 [23]. Cytokine storm can manifest with low albumin level that would be consistent with capillary leak [23][24][25]. Hypoalbuminemia was seen in 12 of 14 patients in this series.…”

Section: Discussion

mentioning

confidence: 67%

N-Adamantyl Phthalimidine: A New Thalidomide-like Drug That Lacks Cereblon Binding and Mitigates Neuronal and Synaptic Loss, Neuroinflammation, and Behavioral Deficits in Traumatic Brain Injury and LPS Challenge

¹

,

²

,

³

et al. 2021

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…61 Excessive or unregulated chronic activation can induce a "cytokine storm" in the brain and result in neurotoxic levels of cytokines and free radicals (e.g., nitric oxide and superoxide), which can damage neurons and initiate a self-perpetuating cycle of inflammatory neurotoxicity. 21,60,62,71 Consistent with work published by others, our CCI-induced moderate TBI provoked activation of microglia and astrocytes in surrounding ipsilateral brain areas (Figures 7 and 8), with a resulting elevation in microglial TNF-α generation (Figure 9). In line with this, significantly lower levels of ramified (resting/ surveillance) microglia expressing P2RY12 were evident in brain ipsilateral to TBI, as compared to the contralateral side (Figure 10C,D).…”

Section: ■ Discussion

supporting

confidence: 89%

Transcriptomic Analysis of the Spleen of Different Chicken Breeds Revealed the Differential Resistance of Salmonella Typhimurium

Elsharkawy

¹

,

Wang

²

,

Ding

³

et al. 2022

Genes

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…The significantly altered pathways after ST infection included neuroactive ligand-receptor interaction and cytokinecytokine receptor interaction, in line with earlier reports [29][30][31]. High doses of Salmonella can result in the production of excess amounts of proinflammatory cytokines, or a "cytokine storm", leading to endotoxin shock or sepsis-related deaths [32][33][34]. Thus, the potential influence of over-expression of inflammatory cytokines due to hypersensitivity response to SE in susceptible birds was also considered in this study.…”

Section: Discussion

supporting

confidence: 80%

Vaping-associated illness: a reassessment

Schiffman

¹

2024

Preprint

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…This can be seen in cytokine storm which has been associated with non-infectious as well as infectious etiologies such as Covid-19 [23]. Cytokine storm can manifest with low albumin level that would be consistent with capillary leak [23][24][25]. Hypoalbuminemia was seen in 12 of 14 patients in this series.…”

Section: Discussion

mentioning

confidence: 67%