Human Chorionic Gonadotropin
- PMID: 30422545
- Bookshelf ID: NBK532950
Human Chorionic Gonadotropin
Excerpt
Human chorionic gonadotropin (hCG) is a hormone produced by trophoblast tissue, which is typically found in early embryos and eventually develops into part of the placenta. Measuring hCG levels can help distinguish between normal and abnormal pregnancies and is also useful for monitoring after a pregnancy loss. In addition, hCG testing can aid in the diagnosis of certain cancers, such as choriocarcinoma and some extra-uterine malignancies. Exogenous administration of hCG as a bolus is standard practice for in vitro fertilization transfer care.
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Sections
- Introduction
- Etiology and Epidemiology
- Pathophysiology
- Specimen Requirements and Procedure
- Diagnostic Tests
- Testing Procedures
- Interfering Factors
- Results, Reporting, and Critical Findings
- Clinical Significance
- Quality Control and Lab Safety
- Enhancing Healthcare Team Outcomes
- Review Questions
- References
References
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- Joyce CM, O'Shea PM, Lynch R, Costelloe SJ, McCarthy TV, Coulter J, Hayes-Ryan D, O'Donoghue K. Proof-of-concept study: Remote capillary blood collection for hCG analysis in early pregnancy. Eur J Obstet Gynecol Reprod Biol. 2024 Sep;300:309-314. - PubMed
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- Cole LA. Immunoassay of human chorionic gonadotropin, its free subunits, and metabolites. Clin Chem. 1997 Dec;43(12):2233-43. - PubMed
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- Greene DN, Schmidt RL, Kamer SM, Grenache DG, Hoke C, Lorey TS. Limitations in qualitative point of care hCG tests for detecting early pregnancy. Clin Chim Acta. 2013 Jan 16;415:317-21. - PubMed
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