DDX56
| DDX56 | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||||||||||||||||
| Aliasi | DDX56 | ||||||||||||||||||||||||
| Vanjski ID-jevi | OMIM: 608023 MGI: 1277172 HomoloGene: 6498 GeneCards: DDX56 | ||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| Ortolozi | |||||||||||||||||||||||||
| Vrste | Čovjek | Miš | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
| Ensembl | |||||||||||||||||||||||||
| UniProt | |||||||||||||||||||||||||
| RefSeq (mRNK) | |||||||||||||||||||||||||
| RefSeq (bjelančevina) | |||||||||||||||||||||||||
| Lokacija (UCSC) | Chr 7: 44.57 – 44.58 Mb | Chr 11: 6.21 – 6.22 Mb | |||||||||||||||||||||||
| PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
| Wikipodaci | |||||||||||||||||||||||||
| |||||||||||||||||||||||||
Vjerovatna ATP-ovisna RNK-helikaza DDX56 jest enzim koji je kod ljudi kodiran genom DDX56.[5][6]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 547 aminokiselina, а molekulska težina 61.590 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MEDSEALGFE | HMGLDPRLLQ | AVTDLGWSRP | TLIQEKAIPL | ALEGKDLLAR | ||||
| ARTGSGKTAA | YAIPMLQLLL | HRKATGPVVE | QAVRGLVLVP | TKELARQAQS | ||||
| MIQQLATYCA | RDVRVANVSA | AEDSVSQRAV | LMEKPDVVVG | TPSRILSHLQ | ||||
| QDSLKLRDSL | ELLVVDEADL | LFSFGFEEEL | KSLLCHLPRI | YQAFLMSATF | ||||
| NEDVQALKEL | ILHNPVTLKL | QESQLPGPDQ | LQQFQVVCET | EEDKFLLLYA | ||||
| LLKLSLIRGK | SLLFVNTLER | SYRLRLFLEQ | FSIPTCVLNG | ELPLRSRCHI | ||||
| ISQFNQGFYD | CVIATDAEVL | GAPVKGKRRG | RGPKGDKASD | PEAGVARGID | ||||
| FHHVSAVLNF | DLPPTPEAYI | HRAGRTARAN | NPGIVLTFVL | PTEQFHLGKI | ||||
| EELLSGENRG | PILLPYQFRM | EEIEGFRYRC | RDAMRSVTKQ | AIREARLKEI | ||||
| KEELLHSEKL | KTYFEDNPRD | LQLLRHDLPL | HPAVVKPHLG | HVPDYLVPPA | ||||
| LRGLVRPHKK | RKKLSSSCRK | AKRAKSQNPL | RSFKHKGKKF | RPTAKPS |
Funkcija
[uredi | uredi izvor]Ovaj gen kodira člana proteinske porodice DEAD-kutija. Proteini iz ove kutije, karakterizirani konzerviranim motivom Asp-Glu-Ala-Asp (DEAD), su pretpostavljene RNK-helikaze. Oni su uključeni u brojne ćelijske procese koji uključuju promjenu sekundarne strukture RNK, kao što su inicijacija translacije, jedarna i mitohondrijska prerada, te sklapanje ribosoma i splajsosoma. Na osnovu njihovih obrazaca distribucije, vjeruje se da su neki članovi ove porodice uključeni u embriogenezu, spermatogenezu i ćelijski rast i diobu. Protein kodiran ovim genom pokazuje ARPaznu aktivnost u prisustvu polinukleotida i asocira na nukleoplazmatske 65S preribosomske čestice. Ovaj gen može biti uključen u sintezu ribosoma, najvjerovatnije tokom sastavljanja velike 60S ribosomske podjedinice.[6]
Reference
[uredi | uredi izvor]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000136271 - Ensembl, maj 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004393 - Ensembl, maj 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Zirwes RF, Eilbracht J, Kneissel S, Schmidt-Zachmann MS (Jul 2000). "A Novel Helicase-Type Protein in the Nucleolus: Protein NOH61". Mol Biol Cell. 11 (4): 1153–67. doi:10.1091/mbc.11.4.1153. PMC 14838. PMID 10749921.
- 1 2 "Entrez Gene: DDX56 DEAD (Asp-Glu-Ala-Asp) box polypeptide 56".
- ↑ "UniProt, Q9NY93" (jezik: eng). Pristupljeno 24. 9. 2021.CS1 održavanje: nepoznati jezik (link)
Dopunska literatura
[uredi | uredi izvor]- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
- Valdez BC, Yang H, Hong E, Sequitin AM (2002). "Genomic structure of newly identified paralogue of RNA helicase II/Gu: detection of pseudogenes and multiple alternatively spliced mRNAs". Gene. 284 (1–2): 53–61. doi:10.1016/S0378-1119(01)00888-5. PMID 11891046.
- Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
