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Annu. Rev. Entomol.
 2021
DOI: 10.1146/annurev-ento-020117-043154
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Engineering the Composition and Fate of Wild Populations with Gene Drive

Bruce A. Hay
1
,
Georg Oberhofer
2
,
Ming Guo
3

Abstract: Insects play important roles as predators, prey, pollinators, recyclers, hosts, parasitoids, and sources of economically important products. They can also destroy crops; wound animals; and serve as vectors for plant, animal, and human diseases. Gene drive—a process by which genes, gene complexes, or chromosomes encoding specific traits are made to spread through wild populations, even if these traits result in a fitness cost to carriers—provides new opportunities for altering populations to benefit humanity an… Show more

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Cited by 90 publications

(90 citation statements)
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“…Outcomes are comparable to those observed when ClvR is introduced at a frequency of 10%, and all elements are intact (Fig. 5d-f re generally detrimental to gene drive (reviewed in 1,3 ). Resistant versions of the essential gene can allow non-ClvR chromosomes to survive in gametes produced by ClvR carriers.…”
Section: Clvr Drive Behavior In Response To Mutations In Cis and Transsupporting
confidence: 60%
“…Sequence polymorphisms (naturally occurring or arising through inaccurate DNA repair) that create uncleavable but functional versions (resistant alleles) of a target gene are generally detrimental to gene drive (reviewed in 1,3 ). Resistant versions of the essential gene can allow non- ClvR chromosomes to survive in gametes produced by ClvR carriers.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Outcomes are comparable to those observed when ClvR is introduced at a frequency of 10%, and all elements are intact (Fig. 5d-f re generally detrimental to gene drive (reviewed in 1,3 ). Resistant versions of the essential gene can allow non-ClvR chromosomes to survive in gametes produced by ClvR carriers.…”
Section: Clvr Drive Behavior In Response To Mutations In Cis and Transsupporting
confidence: 60%
“…Sequence polymorphisms (naturally occurring or arising through inaccurate DNA repair) that create uncleavable but functional versions (resistant alleles) of a target gene are generally detrimental to gene drive (reviewed in 1,3 ). Resistant versions of the essential gene can allow non- ClvR chromosomes to survive in gametes produced by ClvR carriers.…”
Section: Resultsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Rather, to perfectly balance a recessive lethal mutation, drive must be very weak at low frequency, increasing in strength in proportion to allele frequency. One class of gene drive mechanisms that can have this property are those based on toxin–antidote interactions ( 13 , 20 , 21 ). The most promising and easiest to engineer are cleave and rescue systems that use CRISPR/Cas9 technology, in which Cas9 “cleaves” a target gene and creates an edited nonfunctional version which acts as a toxin and the antidote is a recoded version of the target gene that “rescues” function but is resistant to Cas9 cleavage ( 22 , 23 ).…”
Section: Resultsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Rather, to perfectly balance a recessive lethal mutation, drive must be very weak at low frequency, increasing in strength in proportion to allele frequency. One class of gene drive mechanisms that can have this property are those based on toxin-antidote interactions (Hay et al, 2021, Ward et al, 2011, Wade and Beeman, 1994, Davis et al, 2001). The most promising and easiest to engineer are Cleave and Rescue systems that use CRISPR/Cas9 technology, in which Cas9 “cleaves” a target gene and creates an edited non-functional version which acts as a toxin and the antidote is a recoded version of the target gene that “rescues” function but is resistant to Cas9 cleavage (Champer et al, 2020b, Oberhofer et al, 2019).…”
Section: Resultsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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