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Meta-Analysis
. 2020 Sep 11;99(37):e21832.
doi: 10.1097/MD.0000000000021832.

Association between Helicobacter pylori infection and the risk of colorectal cancer: A systematic review and meta-analysis

Yuling Zuo  1 , Zhao Jing  1 , Mingjiang Bie  2 , Chunyan Xu  3 , Xinyu Hao  4 , Baoning Wang  5
Affiliations
Meta-Analysis

Association between Helicobacter pylori infection and the risk of colorectal cancer: A systematic review and meta-analysis

Yuling Zuo et al. Medicine (Baltimore). .

Abstract

Background: The existing evidence on the relationship between Helicobacter pylori infection and the risk of colorectal cancer is inconsistent. We conducted a systematic review with a meta-analysis to explore this relationship and to determine whether the relationship varies according to the study characteristics.

Methods: We searched the PubMed, OVID, EMBASE database, and the reference lists of pertinent articles published up to October 2019 by 2 researchers independently. Summary odds ratios (OR) with their 95% confidence intervals (CIs) were estimated using a random-effects model.

Results: Forty seven studies including 17,416 cases of colorectal cancer (CRC) and 55,811 cases of control were included. Overall, H. pylori infection was associated with an increased risk of CRC (OR = 1.70 95% CI 1.64-1.76, I = 97%), although there was significant heterogeneity among the studies. Subgroup analysis revealed that the positive correlation might vary by the design of study conducted.

Conclusion: This meta-analysis demonstrates a positive association between H. pylori infection and the risk of colorectal cancer.

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Conflict of interest statement

All the authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Flow diagram of studies selection.
Figure 2
Figure 2
Forest plot of seropositivity to H pylori infection and CRC risk by areas and study. Conditional logistic regression models were applied to determine OR (diamonds) and 95% CI (horizontal lines).
Figure 3
Figure 3
Funnel plot for evaluation the publication bias of Helicobacter pylori infection and colorectal cancer risk.
See this image and copyright information in PMC

References

    1. Dekker E, Tanis PJ, Vleugels JLA, et al. Colorectal cancer. Lancet 2019;394:1467–50.. - PubMed
    1. Zhang Y, Chen Z, Li J. The current status of treatment for colorectal cancer in China: a systematic review. Medicine 2017;96:e83242. - PMC - PubMed
    1. Feng RM, Zong YN, Cao SM, et al. Current cancer situation in China: good or bad news from the 2018 global cancer statistics? Cancer Commun 2019;39:212. - PMC - PubMed
    1. Islami F, Chen W, Yu XQ, et al. Cancer deaths and cases attributable to lifestyle factors and infections in China, 2013. Ann Oncol 2017;28:22567–574.. - PubMed
    1. Watari J, Chen N, Amenta PS, et al. Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development. World J Gastroenterol 2014;20:5461–573.. - PMC - PubMed