The Frontiers Policy Labs initiative seeks to strengthen the connection between robust scientific research and informed policymaking. Now is the time to look to science as a tool to enable better, more holistic decision making; an interface through which policy is driven by evidence. To enable that, science must be open, science must be trusted, and science must be accessible. Frontiers Policy Labs provides an evidence-based discussion platform, covering topics where commentaries are judged as scientific pieces, ensuring rigorous and informed contributions to policy development.