{"id":"https://openalex.org/W4224987266","doi":"https://doi.org/10.1109/isbi52829.2022.9761696","title":"Deep Neural Network for Combined Particle Tracking and Colocalization Analysis in Two-Channel Microscopy Images","display_name":"Deep Neural Network for Combined Particle Tracking and Colocalization Analysis in Two-Channel Microscopy Images","publication_year":2022,"publication_date":"2022-03-28","ids":{"openalex":"https://openalex.org/W4224987266","doi":"https://doi.org/10.1109/isbi52829.2022.9761696"},"language":"en","primary_location":{"id":"doi:10.1109/isbi52829.2022.9761696","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi52829.2022.9761696","pdf_url":null,"source":{"id":"https://openalex.org/S4363605129","display_name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005314411","display_name":"Roman Spilger","orcid":"https://orcid.org/0000-0002-3049-7375"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Roman Spilger","raw_affiliation_strings":["Heidelberg University,Biomedical Computer Vision Group, BioQuant, IPMB,Heidelberg,Germany,69120"],"affiliations":[{"raw_affiliation_string":"Heidelberg University,Biomedical Computer Vision Group, BioQuant, IPMB,Heidelberg,Germany,69120","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100447462","display_name":"Jiyoung Lee","orcid":"https://orcid.org/0000-0003-1702-874X"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210112943","display_name":"Department of Virology","ror":"https://ror.org/01xx2ne27","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I157536573","https://openalex.org/I4210096427","https://openalex.org/I4210112943"]},{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Ji-Young Lee","raw_affiliation_strings":["Heidelberg University,Dept. of Infectious Diseases, Molecular Virology","German Center for Infection Research, Heidelberg Partner Site","Dept. of Infectious Diseases, Molecular Virology, Heidelberg University"],"affiliations":[{"raw_affiliation_string":"Heidelberg University,Dept. of Infectious Diseases, Molecular Virology","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210112943"]},{"raw_affiliation_string":"German Center for Infection Research, Heidelberg Partner Site","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Dept. of Infectious Diseases, Molecular Virology, Heidelberg University","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015740141","display_name":"Ralf Bartenschlager","orcid":"https://orcid.org/0000-0001-5601-9307"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210112943","display_name":"Department of Virology","ror":"https://ror.org/01xx2ne27","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I157536573","https://openalex.org/I4210096427","https://openalex.org/I4210112943"]},{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Ralf Bartenschlager","raw_affiliation_strings":["Heidelberg University,Dept. of Infectious Diseases, Molecular Virology","German Center for Infection Research, Heidelberg Partner Site","Dept. of Infectious Diseases, Molecular Virology, Heidelberg University"],"affiliations":[{"raw_affiliation_string":"Heidelberg University,Dept. of Infectious Diseases, Molecular Virology","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210112943"]},{"raw_affiliation_string":"German Center for Infection Research, Heidelberg Partner Site","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Dept. of Infectious Diseases, Molecular Virology, Heidelberg University","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105166471","display_name":"Karl Rohr","orcid":null},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karl Rohr","raw_affiliation_strings":["Heidelberg University,Biomedical Computer Vision Group, BioQuant, IPMB,Heidelberg,Germany,69120"],"affiliations":[{"raw_affiliation_string":"Heidelberg University,Biomedical Computer Vision Group, BioQuant, IPMB,Heidelberg,Germany,69120","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5005314411"],"corresponding_institution_ids":["https://openalex.org/I223822909"],"apc_list":null,"apc_paid":null,"fwci":1.3049,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.84514436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colocalization","display_name":"Colocalization","score":0.9173145294189453},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6797544360160828},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6620391607284546},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.6155749559402466},{"id":"https://openalex.org/keywords/channel","display_name":"Channel (broadcasting)","score":0.6014403700828552},{"id":"https://openalex.org/keywords/tracking","display_name":"Tracking (education)","score":0.5834198594093323},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.56688392162323},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.5567570924758911},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.4451448619365692},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.4297095537185669},{"id":"https://openalex.org/keywords/fluorescence-microscope","display_name":"Fluorescence microscope","score":0.4135086238384247},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.19099414348602295},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.165442556142807},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.13930043578147888},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.08157840371131897},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.06780213117599487}],"concepts":[{"id":"https://openalex.org/C40209533","wikidata":"https://www.wikidata.org/wiki/Q5147828","display_name":"Colocalization","level":2,"score":0.9173145294189453},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6797544360160828},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6620391607284546},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.6155749559402466},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.6014403700828552},{"id":"https://openalex.org/C2775936607","wikidata":"https://www.wikidata.org/wiki/Q466845","display_name":"Tracking (education)","level":2,"score":0.5834198594093323},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.56688392162323},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.5567570924758911},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4451448619365692},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.4297095537185669},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.4135086238384247},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.19099414348602295},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.165442556142807},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.13930043578147888},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08157840371131897},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.06780213117599487},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C19417346","wikidata":"https://www.wikidata.org/wiki/Q7922","display_name":"Pedagogy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi52829.2022.9761696","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi52829.2022.9761696","pdf_url":null,"source":{"id":"https://openalex.org/S4363605129","display_name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1485009520","https://openalex.org/W1973421894","https://openalex.org/W1982221523","https://openalex.org/W2022050193","https://openalex.org/W2103706175","https://openalex.org/W2129140439","https://openalex.org/W2143623375","https://openalex.org/W2159477924","https://openalex.org/W2529052661","https://openalex.org/W2621053731","https://openalex.org/W2670707886","https://openalex.org/W2884561390","https://openalex.org/W2962874213","https://openalex.org/W2999435349","https://openalex.org/W3039859427","https://openalex.org/W6628877408"],"related_works":["https://openalex.org/W4211107619","https://openalex.org/W2161433272","https://openalex.org/W2894139091","https://openalex.org/W1637909","https://openalex.org/W1983780159","https://openalex.org/W659245948","https://openalex.org/W2094643072","https://openalex.org/W4206210906","https://openalex.org/W2793462084","https://openalex.org/W2087957833"],"abstract_inverted_index":{"Analyzing":[0],"protein":[1],"dynamics":[2],"in":[3,28],"multi-channel":[4],"fluorescence":[5,100],"microscopy":[6,30,101],"data":[7],"is":[8,35],"important":[9],"to":[10,48,68],"understand":[11],"biological":[12],"processes.":[13],"We":[14,85],"present":[15],"a":[16,38],"novel":[17],"deep":[18],"learning":[19],"approach":[20,34,92,108],"for":[21],"combined":[22],"particle":[23],"tracking":[24],"and":[25,44,52,97],"colocalization":[26,46],"analysis":[27],"two-channel":[29,99],"image":[31,62],"sequences.":[32],"The":[33],"based":[36,93],"on":[37,94],"convolutional":[39],"long":[40],"short-term":[41],"memory":[42],"network":[43],"exploits":[45],"information":[47],"improve":[49],"tracking.":[50],"Short":[51],"long-term":[53],"temporal":[54],"dependencies":[55],"of":[56,89],"object":[57],"motion":[58],"as":[59,61],"well":[60],"intensities":[63],"are":[64,78],"taken":[65],"into":[66],"account":[67],"compute":[69],"assignment":[70],"probabilities":[71,77],"jointly":[72],"across":[73],"multiple":[74],"detections.":[75],"Colocalization":[76],"also":[79],"determined":[80],"by":[81],"the":[82,87,90],"neural":[83],"network.":[84],"evaluated":[86],"performance":[88],"proposed":[91],"synthetic":[95],"images":[96],"real":[98],"data.":[102],"It":[103],"turned":[104],"out":[105],"that":[106],"our":[107],"outperforms":[109],"previous":[110],"methods.":[111]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-02-20T06:14:18.993340","created_date":"2025-10-10T00:00:00"}