Genomic and molecular characterization of esophageal squamous cell carcinoma

¹

,

²

,

³

et al. 2020

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…This suggests similar molecular cancer mechanisms at the RNA level between the two groups, rather than a distinguishable and specific signature for hESCC. Activation of Wnt signaling and Notch pathways, earlier shown to be involved in development of ESCC, are not clearly different between hESCC and sESCC in our data [6,7,[9][10][11][12]. These data differ from previous results, which concluded that the RNA expression profiles of second primary radiation-…”

Section: Discussion

contrasting

confidence: 99%

Gene expression profiles of esophageal squamous cell cancers in Hodgkin lymphoma survivors versus sporadic cases

¹

,

²

,

³

et al. 2020

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…This suggests similar molecular cancer mechanisms at the RNA level between the two groups, rather than a distinguishable and specific signature for hESCC. Activation of Wnt signaling and Notch pathways, earlier shown to be involved in development of ESCC, are not clearly different between hESCC and sESCC in our data [6,7,[9][10][11][12]. These data differ from previous results, which concluded that the RNA expression profiles of second primary radiation-…”

Section: Discussion

contrasting

confidence: 99%

Mutational Landscape of Esophageal Squamous Cell Carcinoma in an Indian Cohort

Mangalaparthi

¹

,

Patel

²

,

Khan

³

et al. 2020

Front. Oncol.

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…We compared the mutation load in our cohort to published ESCC genomic profiling studies from Chinese and Japanese cohorts. We did not observe a significant difference in mutation load between smokers and non-smokers in Chinese as well as Japanese cohorts which was in line with observations from our cohort ( 12 – 14 , 37 , 50 , 51 ). This is unlike lung cancers where lung squamous cell carcinoma and lung adenocarcinoma exhibit a high mutation load in smokers compared to non-smokers ( 5 , 52 – 54 ) ( Figure 3 , Supplementary Table 5 ).…”

Section: Results

supporting

confidence: 92%

“…TP53 (71%), TTN (64%), CSMD3 (43%), SYNE1 (28%), LRP1B (25%), PIK3CA (25%), DNAH5 (21%), and NOTCH1 (14%) were recurrently mutated genes in our ESCC cohort ( Figure 1 ). TP53 mutations were identified in 71% of the samples which is in concordance with the reported mutation frequency of ~80% in previous studies ( 12 , 13 ). NF1 is a well-known tumor suppressor gene and it was mutated in 11% of the samples and ZFHX4 in 21% of the samples.…”

Section: Results

supporting

confidence: 91%

Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting

Liu

¹

,

Xie

²

,

He

³

et al. 2021

Nat Commun

Self Cite

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…In particular, TP53 was upregulated, whereas ERBB2 and ZNF750 were downregulated in tumors (fold-change >1.5) (Supplementary Data 2a ). Downregulation of ZNF750 was consistent with previous studies showing that ZNF750 is expressed at a very low levels via truncating mutations and functions as a tumor suppressor in EC 5 , 7 . Of those 30 SMGs quantifiable in our proteomics data, nine were associated with survival outcomes.…”

Section: Results

supporting

confidence: 91%

Gene expression profiles of esophageal squamous cell cancers in Hodgkin lymphoma survivors versus sporadic cases

¹

,

²

,

³

et al. 2020

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…This suggests similar molecular cancer mechanisms at the RNA level between the two groups, rather than a distinguishable and specific signature for hESCC. Activation of Wnt signaling and Notch pathways, earlier shown to be involved in development of ESCC, are not clearly different between hESCC and sESCC in our data [6,7,[9][10][11][12]. These data differ from previous results, which concluded that the RNA expression profiles of second primary radiation-…”

Section: Discussion

contrasting

confidence: 99%

Mutational Landscape of Esophageal Squamous Cell Carcinoma in an Indian Cohort

Mangalaparthi

¹

,

Patel

²

,

Khan

³

et al. 2020

Front. Oncol.

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…We compared the mutation load in our cohort to published ESCC genomic profiling studies from Chinese and Japanese cohorts. We did not observe a significant difference in mutation load between smokers and non-smokers in Chinese as well as Japanese cohorts which was in line with observations from our cohort ( 12 – 14 , 37 , 50 , 51 ). This is unlike lung cancers where lung squamous cell carcinoma and lung adenocarcinoma exhibit a high mutation load in smokers compared to non-smokers ( 5 , 52 – 54 ) ( Figure 3 , Supplementary Table 5 ).…”

Section: Results

supporting

confidence: 92%

“…TP53 (71%), TTN (64%), CSMD3 (43%), SYNE1 (28%), LRP1B (25%), PIK3CA (25%), DNAH5 (21%), and NOTCH1 (14%) were recurrently mutated genes in our ESCC cohort ( Figure 1 ). TP53 mutations were identified in 71% of the samples which is in concordance with the reported mutation frequency of ~80% in previous studies ( 12 , 13 ). NF1 is a well-known tumor suppressor gene and it was mutated in 11% of the samples and ZFHX4 in 21% of the samples.…”

Section: Results

supporting

confidence: 91%

Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting

Liu

¹

,

Xie

²

,

He

³

et al. 2021

Nat Commun

Self Cite

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…In particular, TP53 was upregulated, whereas ERBB2 and ZNF750 were downregulated in tumors (fold-change >1.5) (Supplementary Data 2a ). Downregulation of ZNF750 was consistent with previous studies showing that ZNF750 is expressed at a very low levels via truncating mutations and functions as a tumor suppressor in EC 5 , 7 . Of those 30 SMGs quantifiable in our proteomics data, nine were associated with survival outcomes.…”

Section: Results

supporting

confidence: 91%

Gene expression profiles of esophageal squamous cell cancers in Hodgkin lymphoma survivors versus sporadic cases

¹

,

²

,

³

et al. 2020

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…This suggests similar molecular cancer mechanisms at the RNA level between the two groups, rather than a distinguishable and specific signature for hESCC. Activation of Wnt signaling and Notch pathways, earlier shown to be involved in development of ESCC, are not clearly different between hESCC and sESCC in our data [6,7,[9][10][11][12]. These data differ from previous results, which concluded that the RNA expression profiles of second primary radiation-…”

Section: Discussion

contrasting

confidence: 99%

Mutational Landscape of Esophageal Squamous Cell Carcinoma in an Indian Cohort

Mangalaparthi

¹

,

Patel

²

,

Khan

³

et al. 2020

Front. Oncol.

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…We compared the mutation load in our cohort to published ESCC genomic profiling studies from Chinese and Japanese cohorts. We did not observe a significant difference in mutation load between smokers and non-smokers in Chinese as well as Japanese cohorts which was in line with observations from our cohort ( 12 – 14 , 37 , 50 , 51 ). This is unlike lung cancers where lung squamous cell carcinoma and lung adenocarcinoma exhibit a high mutation load in smokers compared to non-smokers ( 5 , 52 – 54 ) ( Figure 3 , Supplementary Table 5 ).…”

Section: Results

supporting

confidence: 92%

“…TP53 (71%), TTN (64%), CSMD3 (43%), SYNE1 (28%), LRP1B (25%), PIK3CA (25%), DNAH5 (21%), and NOTCH1 (14%) were recurrently mutated genes in our ESCC cohort ( Figure 1 ). TP53 mutations were identified in 71% of the samples which is in concordance with the reported mutation frequency of ~80% in previous studies ( 12 , 13 ). NF1 is a well-known tumor suppressor gene and it was mutated in 11% of the samples and ZFHX4 in 21% of the samples.…”

Section: Results

supporting

confidence: 91%

Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting

Liu

¹

,

Xie

²

,

He

³

et al. 2021

Nat Commun

Self Cite

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…In particular, TP53 was upregulated, whereas ERBB2 and ZNF750 were downregulated in tumors (fold-change >1.5) (Supplementary Data 2a ). Downregulation of ZNF750 was consistent with previous studies showing that ZNF750 is expressed at a very low levels via truncating mutations and functions as a tumor suppressor in EC 5 , 7 . Of those 30 SMGs quantifiable in our proteomics data, nine were associated with survival outcomes.…”

Section: Results

supporting

confidence: 91%