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. 2019 May 17;364(6441):636-637.
doi: 10.1126/science.aaw1299.

Senolytic therapies for healthy longevity

Jan M van Deursen  1
Affiliations

Senolytic therapies for healthy longevity

Jan M van Deursen. Science. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

COI: J.M.v.D. is a cofounder of Unity Biotechnology and an inventor on patents licensed to or filed by Unity Biotechnology.

Figures

Figure.
Figure.. Senolytic therapies for optimized aging.
SNCs resist cell death by activating prosurvival and inhibiting pro-apoptotic pathways. First generation senolytic drugs developed to effectively target key components of these pathways eliminate SNCs and thereby the SASP that drives diseases of aging. Clinical testing of one such drug, UBX0101, is ongoing for the treatment of osteoarthritis, with a second drug, UBX1967, advancing to human testing for eye diseases. Development of highly selective senolytics that safely and effectively eliminate SNCs upon systemic administration for treatment of neurodegenerative or cardiovascular diseases, among others, awaits further advancements from fundamental and translational research on SNCs.
See this image and copyright information in PMC

References

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