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Review
. 2015 Mar 30:6:49.
doi: 10.4103/2152-7806.154273. eCollection 2015.

Longevity and compression of morbidity from a neuroscience perspective: Do we have a duty to die by a certain age?

Miguel A Faria  1
Affiliations
Review

Longevity and compression of morbidity from a neuroscience perspective: Do we have a duty to die by a certain age?

Miguel A Faria. Surg Neurol Int. .

Abstract

The search for longevity, if not for immortality itself, has been as old as recorded history. The great strides made in the standard of living and the advances in scientific medicine, have resulted in unprecedented increases in longevity, concomitant with improved quality of life. Thanks to medical progress senior citizens, particularly octogenarians, have become the fastest growing segment of the population and the number of centenarians is increasing, even though in the last two decades, spurred by the bioethics movement, the priority assigned to the prolongation of lifespan has taken a back seat to the containment of health care costs. This article describes what individuals can do to lead healthy lifestyles and increase longevity, concomitant with preservation of quality of life until the very end of life-as postulated by Dr. James F. Fries' hypothesis of the compression of morbidity. This review article investigates the contention of bioethicist Dr. Ezekiel Emanuel that Fries' theory is a "fantasy" and not a realistic possibility. In this context recent advances in neurobiology, epigenetics, and aging are described, and the hypothesis of the compression of morbidity re-examined. We find that people are not only living longer but are remaining healthier. Recent studies suggest that brain plasticity develops and potential neurogenesis occurs in those individuals who continue to be mentally and physically active allowing them to thrive well into old age. Controlled studies as well as Medicare spending data strongly corroborate Fries' predictions and support my conclusion that compression of morbidity should be upgraded from a hypothesis to a theory. Lastly, leisure in association with or without retirement is discussed and suggestions are made as to how to use this time to remain intellectually sharp and physically vigorous until the very end of life.

Keywords: Bioethics; brain plasticity; compression of morbidity; end of life; healthy lifestyles; longevity.

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Figures

Figure 1
Figure 1
Gilgamesh holding a lion from an Assyrian relief. Museé du Louvre, Paris, France
Figure 2
Figure 2
Bioethics. Courtesy of the Institute of Catholic Bioethics, Saint Joseph's University, Philadelphia
Figure 3
Figure 3
Centennial birthday celebrations will become more common! Courtesy of 23andMeBlog
Figure 4
Figure 4
Weight Control. Courtesy of Medline Plus, a service of the U.S. National Library of Medicine and the National Institute of Health (NIH)
Figure 5
Figure 5
Abstract concept of brain plasticity. Courtesy of Andy Spencer, MindScape Instructor, UK
Figure 6
Figure 6
Epigenetic factors and gene activation in poor health with reduced longevity. Courtesy of Joseph C. Maroon, MD
Figure 7
Figure 7
Epigenetic factors and gene activation in good health with increased longevity. Courtesy of Joseph C. Maroon, MD
Figure 8
Figure 8
Illustration of neuron and synapses. Courtesy of Wikipedia
Figure 9
Figure 9
Illustration of synaptic transmission. Courtesy of Wikipedia
Figure 10
Figure 10
Octogenarian Olympian Johanna Quass (86) of Saxony, Germany (April 2012). Courtesy of Common Constitutionalist
Figure 11
Figure 11
Dr. James C. Fries and his wife Sarah. Courtesy of Stanford University
Figure 12
Figure 12
Aristotle, author of Metaphysics and Nicomachean Ethics and the definer of the meaning of the philosophic moral and intellectual good life
See this image and copyright information in PMC

References

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