YY1 Dynodwyr Cyfenwau YY1 Dynodwyr allanol OMIM: 600013 HomoloGene: 2556 GeneCards: YY1 Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001106 transcription corepressor activity • GO:0001105 transcription coactivator activity • zinc ion binding • metal ion binding • GO:0001948, GO:0016582 protein binding • four-way junction DNA binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • RNA binding • nucleic acid binding • SMAD binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • histone deacetylase binding Cydrannau o'r gell • Ino80 complex • nuclear matrix • cnewyllyn cell • nucleoplasm • transcription regulator complex • cytoplasm • PcG protein complex Prosesau biolegol • cell differentiation • DNA recombination • GO:0009373 regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • cellular response to UV • negative regulation of gene expression • transcription, DNA-templated • cellular response to DNA damage stimulus • double-strand break repair via homologous recombination • spermatogenesis • GO:0100026 DNA repair • protein deubiquitination • negative regulation of interferon-beta production • GO:1901227 negative regulation of transcription by RNA polymerase II • RNA localization • anterior/posterior pattern specification • response to UV-C • GO:1901313 positive regulation of gene expression • response to prostaglandin F • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • camera-type eye morphogenesis • GO:0051312, GO:0007083 chromosome organization • cellular response to interleukin-1 • negative regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of cell growth involved in cardiac muscle cell development Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[ 1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn YY1 yw YY1 a elwir hefyd yn YY1 transcription factor a Transcriptional repressor protein YY1 (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q32.2.[ 2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn YY1.
DELTA
NF-E1
UCRBP
GADEVS
INO80S
YIN-YANG-1
"Significance of the pathogenic mutation T372R in the Yin Yang 1 protein interaction with DNA--thermodynamic studies. ". FEBS Lett . 2016. PMID 26910132 . "Yin Yang 1-mediated epigenetic silencing of tumour-suppressive microRNAs activates nuclear factor-κB in hepatocellular carcinoma. ". J Pathol . 2016. PMID 26800240 . "YY1 Is a Structural Regulator of Enhancer-Promoter Loops. ". Cell . 2017. PMID 29224777 . "YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction. ". Am J Hum Genet . 2017. PMID 28575647 . "The zinc fingers of YY1 bind single-stranded RNA with low sequence specificity. ". Nucleic Acids Res . 2016. PMID 27369384 .
