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Direct pore-pressure measurements show that tensile cracks in water-saturated cement generate local underpressure, increasing fracture resistance and reducing the size of the damage zone as crack speed rises.

This study establishes a zebrafish inner ear hair cell injury model, characterizes hair cell regeneration at cellular and single-cell transcriptomic levels, and identifies dlx5a as a key regulator of spontaneous regeneration.

C-lignin is an attractive renewable feedstock for producing catechols, but its strong chemical bonds make it difficult to break down selectively. Here, the authors develop a low-loading Co–Zn dual single-atom catalyst that enables efficient C-lignin hydrogenolysis, providing a sustainable route to valuable aromatic chemicals.

GABAA αβδ receptors regulate tonic inhibitory neurotransmission neuronal excitability and contribute to sleep, mood and motor coordination. Here, we show the subunit arrangement and molecular mechanism of modulation by a δ-subunit selective drug.

Photonic processors can accelerate large-scale data processing but often target a single fixed task. Here, the authors demonstrate a reconfigurable photonic processor that can be partitioned into functional blocks to perform three optical convolution tasks concurrently.

Antimicrobial resistance in invasive Salmonella is an escalating global health threat, yet its global trends and genomic evidence remain poorly understood. Wang and Xu et al. use a state-of-the-art pipeline integrating global genomics to reveal emergence and spatiotemporal patterns of WHO priority antibiotic resistance in invasive Salmonella.

Here, the authors demonstrate that LEDGF/p75 directs lentiviral integration into linker DNA within H3K36me3 chromatin while inhibiting integration into unmodified chromatin. Cryo-EM structures reveal that the host factor profoundly reshapes the intasome target DNA binding platform.

Escin Ia is a clinically important triterpenoid saponin from Aesculus chinensis. Here the authors identify ten biosynthetic enzymes and reconstitute the Escin 1a production in Nicotiana benthamiana.

Genetic risk of complex diseases poses unique challenges. Here, the authors develop a locus-specific stratification and gene regulatory prioritisation strategy to address issues arising from multi-signals in complex diseases.

Non-volatile control of superconductivity is desirable for integrating memory with quantum devices. Here, the authors show that gate cycling imprints superconducting memory in AlO_x/KTaO₃ heterostructures, which can be erased optically via lattice excitations and vacancy trapping, both actions feasible at cryogenic temperatures.

The study identified Mycobacterium abscessus-induced DNA damage as a driver of senescence through reprogramming of alveolar macrophages. Treatment of navitoclax in chronic infection model reduced bacterial burden.

This study shows that bankfull discharge, the flow a river carries before overflowing its banks, recurs at different rates across climate zones, suggesting that the widely used 2-year assumption may bias flood estimates.

When people listen to music, they often imagine remarkably similar stories. The authors show these shared imaginings selectively rely on stimulus-specific patterns in a set of modality-general brain regions.

Weather forecasting and climate prediction have long developed in isolation. This Perspective argues that artificial intelligence is dissolving that divide, enabling unified Earth-system models that span from tomorrow’s storms to the climate of coming decades.

The authors investigate the attribution of diffusion model outputs to training data and show that generated samples can become unattributable when models are trained on large datasets. They introduce a model ablation method that enables efficient removal of training examples without retraining.

AI can uncover problem-solving strategies beyond human discovery. Here, the authors show that AI-discovered strategies propagate and persist in human populations, producing cultural shifts when non-trivial, learnable, and advantageous.

Misalignment between health aid and country-level disease burden can leave populations without the necessary support for major health challenges. Here the authors report a machine learning analysis of global health aid and conclude that aid is often misaligned with country-level disease burden, with non-communicable diseases receiving limited aid despite their large global burden.

Narwhal tusks are macroscopically helical and chiral. This structure originates from left- and right-handed helices of tusk nanostructural components. The double helix creates a straight, mechanically stable tusk with highly anisotropic mechanical properties.