Sensing trouble in their relationship, Lois and Peter go on a second honeymoon. All is well, until Peter drives the car into a tree and they are forced to stay at Mel Gibson's resort. While looking around they find a reel for The Passion of the Christ 2, and decide that for the good of mankind that they must destroy it. Meanwhile, Brian helps Chris get revenge on another student after he is framed, caught with liquor at a school dance.

When Chris' teacher wins the lottery and quits Brian fills in as his teacher. That is until he is moved to teach the troubled students. In Brian’s stead, a new lovely teacher moves in attracting the attention of Chris. Noticing the crush, the teacher promises to be with him if he can kill her husband.

Jealous over his friend’s achievements, Peter sets out to make a world record. Unfortunately for Peter he chooses to be the man to eat the most nickels, making him blind with nickel poisoning. Meanwhile, Quagmire has been conditioned to be a functioning member of society again.

After being rejected for a date, Meg gets an ultimate makeover which instantly makes her popular. At the same time Peter and the gang try to make their favorite bar more popular by bringing in karaoke. After their warm reception they try to sing elsewhere, until Peter's friends ditch him. In an impromptu bit the rest of the Griffins fill in and win over the audience. Eventually the popularity of the group grows so much that they even get to perform on Saturday Night Live.

When Quagmire is caught sleeping with Cleveland's wife, he must hide to get away from the rage of a normally calm Cleveland Brown.

Peter believes himself to be a genius after a well played game of the pre-school edition of Trivial Pursuit. Sick of all the bragging, Brian challenges Peter to take an IQ test. When the results come back it turns out that Peter is actually mentally retarded.

Brian thinks that he may have actually found true love while participating on the television show The Bachlorette. Meanwhile, Chirs struggles with a pimple.

To pay off a pharmaceutical debt, Peter sells Meg. Meanwhile, Lois interviews applicants for a replacement babysitter for Stewie.

After stealing a ham from a supermarket, Lois gets a charge and decides to continue her new thieving habit. Eventually Joe catches Lois and sends her off to prison. Willing to do anything to help, the Griffins plot to help Lois escape, and hide away in "Asiantown". But how long can they outrun Joe?

Lois works towards one of her teenage aspirations, and becomes a fashion model. When she becomes popular, she starts taking up the bad habits of success. Peter becomes very jealous, and can't stand that other men look at his wife. Meanwhile, Brian works for Stewie to pay for his worms medication.

Peter becomes good friends with James Woods when James comes to town to sit in a meeting for the change of James Woods Regional High School to a name honoring Martin Luther King Jr. Lois becomes jealous over the amount of time that Peter starts spending with James Woods.

When Peter and the gang get stranded on a desert island, things get shaken up in Quahog. Most notably, Brian marries Lois, but they sleep in separate beds.

Nervous about freshman hazing rituals, Chris takes Brian's suggestion and goes into the Peace Corps. When he arrives in South America, Chris becomes popular with the natives and even marries the chief’s daughter. Meanwhile, Peter tries a new career, working at the Pawtucket Brewery.

When an actors antics are edited out of the Emmy's, Peter decides to make his own television station. Peter's television network, PTV, shows programs in their unedited form, which gets Lois irritated. Not happy with the content Lois goes right to the FCC, which quickly puts an end to PTV; but the FCC doesn’t stop there.

Brian almost gets his dream job of working for The New Yorker, but is fired when it is found out that he has not complete college. With only one course needed to graduate, Brain goes back to college, with Stewie tagging along. With Brian studying hard, Stewie takes up the party scene at school. Meanwhile, Peter and the gang decide to become a real life version of the A-Team after winning best costumes at the 80's TV Show Convention.

When Lois gets worried over Stewie's behavior, she recommends that Peter spend more time with his son. Peter learns that Stewie likes it when he hurts Lois, and like always, Peter takes it too far. Meanwhile, Chris is sent over to do chores at their neighbor Herbert's place after hitting a baseball through his window.

After finding evidence that she has a brother, Lois goes to a mental hospital to talk to him. Blinded by the fact that she has a sibling, Lois takes her brother into the Griffin's home. With lapses of old mental trauma, Lois' brother resorts to strangling fat people. Can Lois save her husband from her brother?

When Peter's religous father comes to town, he challanges Peter to look at his life and find religion himself. Peter then decides to open up his own church, the First United Church of the Fonz.

Brian becomes depressed after getting hit by Peter's car. But with help from Frank Sinatra Jr., Brian and Stewie transform into rat packers. Meanwhile, Meg makes a new friend and is invited to hang out with her. Unfortunately for Meg, she is invited to a lesbian club, and she is not a lesbian.

After impressing Tom Brady at a high school reunion, Peter is given a chance to play for the New England Patriots. Peter's time on the Patriots is cut short however when his ego becomes too much for the team to handle. But not wanting to give up, Peter takes his new team the London Silly Nannies and challenges the Patriots. Meanwhile, Stewie becomes a vicious bookie.

Quagmire gives up his philandering ways and settles down with the Griffin's new maid. Irritated by this change, Peter is set to bring the old Quagmire back. Meanwhile, Stewie's teeth cause breast feeding problems for Lois.

When Lois has a pregnancy scare, Peter decides to get a vasectomy, but not before freezing some seamen just in case. But as always things go awry and a lesbian couple ends up with Peter's sample, creating Bertram. Bertram, who has appeared once before, is Stewie's sworn enemy. But which child with world domination plans will succeed?

Peter and Lois go back to their hippie ways when they return to folk singing. Meanwhile, Meg begins an innocent relationship with Mayor Adam West, much to the chagrin of Brian.

When Peter makes his own erotic book, it does well enough that he makes it into an audio tape series. After a car accident that is attributed to the tape, the publisher, Carter Pewterschmidt, is sued for all he owns. Vowing revenge, Lois' father goes to Quahog to kill Peter, only to be convinced to stay in the Griffin's home.

Just as Brian's gay cousin comes to town to get married to his boyfriend, Mayor Adam West passes a bill to outlaw gay marriages. Now it is up to Brian to defend gay marriage.

After Peter digs up a skull of a Native American in his back yard, the Griffins are haunted by a poltergeist.

When the Griffins get robbed, the family runs into Peter's panic room to escape the trespassers. Now isolated and trapped, Peter insists the family know about their ancestry and narrates a chain of events in world history that explain the Griffin name. Meanwhile, after Meg is chosen to go back into the house, she scares off the robbers in an unexpected way.

After nearly drowning, and finding a scary vision of hell, Stewie decides to try to be nicer to his family. But Stewie's adventure really kicks off when he sees a man that looks like an older duplicate of himself on the television, so Stewie and Brian go to find him. Meanwhile, because of his brutal honesty Peter gets a job doing editorial pieces for the news station.

Stewie and Brian tag along with Quagmire on a cross country trip, in order to find the man that Stewie believes to be his father. Meanwhile, Peter and Lois teach Meg and Chris how to date.

Stewie finds out that the man that he saw on television is actually himself from thirty-four years in the future. Back in time on vacation, Stu, tries to flee only to have Stewie grab onto him, teleporting both Stewies into the future. Upon viewing his future, Stewie tries to fix things, and only causes changes in the past.