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Review
. 2002;3(1):REVIEWS0001.
doi: 10.1186/gb-2001-3-1-reviews0001. Epub 2001 Dec 20.

Dating branches on the tree of life using DNA

Gregory A Wray  1
Affiliations
Review

Dating branches on the tree of life using DNA

Gregory A Wray. Genome Biol. 2002.

Abstract

The use of DNA sequences to estimate the timing of evolutionary events is increasingly popular, although it is fraught with practical difficulties. But the exponential growth of relevant information and improved methods of analysis are providing increasingly reliable sequence-derived dates, and it may become possible to reconcile fossil-derived and molecular estimates of divergence times within the next few years.

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Figures

Figure 1
Figure 1
Two approaches to dating evolutionary divergence times. Lineages x, y, z, i and j are shown going back (down) from the present day. Thick bars represent periods for which there is a fossil record for the lineage; dotted lines represent 'ghost' lineages, times when a group is inferred to have been present but left no record [44]. Horizontal lines represent occurrences of a fossil from the lineage in the record; dt(x,y) indicates the date of divergence of lineage x from lineage y; i and j are lineages for which no fossil record is available. (a) Discovery of older fossils of one lineage (red) can alter our views of how the various groups evolved. (b) Calibration of divergence times from sequences using fossil record dates. First, rates of sequence divergence are calibrated using taxa for which a reliable fossil record is available. Gd represents the genetic distance of present-day species from each other, derived from sequence data. A mean rate of sequence substitution is then calculated from a regression of these calibration points, and is used (right) to compute divergence times (gd(x,i) and gd(x,j)) between taxa for which the fossil record is not reliable.
Figure 2
Figure 2
Revised chronology of the 'Tree of Life'. The present is represented by the horizontal line at the top and geological periods are shown on the left with their approximate dates. The Phanerozoic era encompasses the Paleozoic, Mesozoic and Cenozoic (Cen) eras. (a) All organisms; (b) multicellular organisms; (c) amniotes. A variety of important evolutionary events have been estimated using data from fossils (gray horizontal lines) or sequences (black horizontal lines). See the text for discussion of specific divergence times. Where multiple estimates from sequence data have been made, the midpoint of the range is shown.
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