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| Major junctions | |
| From | Eynatten (Belgium) |
| To | Luxembourg City (Luxembourg) |
| Location | |
| Countries |  Belgium Luxembourg |
| Highway system | |
E 421 is a European B class road in Belgium and Luxembourg, connecting the cities Eynatten - Eupen - St. Vith - Luxembourg City
Roads in Luxembourg | |
|---|---|
| Motorways/Autoroutes | |
| E-roads | |
| N-roads | |
| CR-roads | |
| Streets | |
| Interchanges | |
This list is incomplete. | |
